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    Hypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaques

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    Date
    2018-02-28
    Author
    Li, Hongzhao
    Li, Lin
    Liu, Lewis
    Omange, Were
    Toledo, Nikki
    Kashem, Mohammad
    Hai, Yan
    Liang, Binhua
    Plummer, Francis
    Luo, Ma
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    Abstract
    Simian immunodeficiency virus (SIV) infection of Mauritian cynomolgus macaques (MCMs) is an increasingly important nonhuman primate model for HIV vaccine research. We previously reported that in MCMs anti-SIV antibodies can be naturally developed without exogenous infection or vaccination, and that a vaccine targeting SIV protease cleavage sites (PCS) can cross-induce antibodies to non-PCS SIV antigens. We speculate that this is potentially caused by the existence of endogenous SIV-like antigens. External stimuli (such as environmental factors and vaccination) may induce expression of endogenous SIV-like antigens to elicit these antibodies. Database and mass spectrometry analyses were conducted to search for such antigens. We identified endogenous SIV-like DNA sequences in cynomolgus macaque genome and non-PCS peptide homologous to SIV Env protein in PBMCs of a PCS-vaccinated monkey. Our preliminary insights suggest that endogenous SIV-like antigens may be one of the possible reasons for the natural and cross-inducible SIV antibodies in MCMs.
    URI
    http://hdl.handle.net/1993/35799
    DOI
    10.6026/97320630014048
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    • Rady Faculty of Health Sciences Scholarly Works [1296]
    • University of Manitoba Scholarship [1981]

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