Efficacy of intrapleural fibrinolytic therapy as first line treatment in complicated pleural effusions or empyema
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Date
2020
Authors
Oxenforth, Kailey
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Abstract
BACKGROUND: There are various treatment options for empyema and complicated pleural effusion, most of them requiring an invasive procedure. The use of intrapleural fibrinolytic therapy may prevent a more invasive surgical procedure. OBJECTIVES: To determine if intrapleural fibrinolytic therapy is an effective treatment in empyema or complicated pleural effusions. METHODS: A primary systematic literary search was conducted using the online databases Embase and MEDLINE. A secondary search was then conducted from the references of primary search results. Five articles were used within analysis and were either randomized controlled trials or retrospective reviews.
RESULTS: A total of five studies were used from the primary and secondary search out of theoriginal 65 articles found. DISCUSSION: A total of five studies were used within the review, three were randomized controlled trials and two were retrospective reviews. Three out of the five studies included showed statistical significance in the use of intrapleural fibrinolytic therapy as treatment for illness and prevention of surgical intervention.
CONCLUSION: Intrapleural fibrinolytic therapy has been shown to be statistically significant in treatment of empyema and complicated pleural effusions as well as reduction in need of surgical intervention, however there are limitations to the results. KEYWORDS: Empyema, Complicated Pneumonia, Tissue Plasminogen Activator, Dornase
Alpha.
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empyema, complicated pneumonia, tissue plasminogen activator, dornase alpha