• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • Rady Faculty of Health Sciences
    • College of Medicine - B.Sc. (Med) Projects
    • View Item
    •   MSpace Home
    • Rady Faculty of Health Sciences
    • College of Medicine - B.Sc. (Med) Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Intraoperative prediction of cardiac surgery-associated acute kidney injury

    Thumbnail
    View/Open
    BSc(Med) Final Research Report (772.8Kb)
    Date
    2015-08-07
    Author
    Crosina, Jordan
    Metadata
    Show full item record
    Abstract
    Cardiac surgery associated acute kidney injury (CSA-AKI) is a potentially lethal complication which occurs in up to 30% of cardiac surgery patients. When the injury is severe enough to necessitate dialysis (which occurs in approximately 1% to 2% of patients) it confers a 19-fold increase in the odds of death. Even when the injury is relatively modest (i.e. a 25 % rise in postoperative serum creatinine), it is independently associated with morbidity and mortality. A major barrier to preventing CSA-AKI is the lack of available strategies for early detection of kidney injury. Work done by our team has established Hepcidin-25 as a novel urine biomarker of CSA-AKI. Newer data suggest NGAL, OSMR, MMP-2, and Klotho are also potential early biomarkers of CSAAKI. Objective: To study the value of 5 urine and serum biomarkers in the diagnosis of incipient CSA-AKI. A unique and novel aspect of our project will be assessing the value of intraoperative measurements of these biomarkers. Design: Prospective cohort study of 350 cardiac surgery patients (280 patients have already been recruited)
    URI
    http://hdl.handle.net/1993/33155
    Collections
    • College of Medicine - B.Sc. (Med) Projects [206]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV