Anti-gravity exercise, creatine supplementation, and serum S100A8/A9 in knee osteoarthritis

Abstract

Knee osteoarthritis (OA) is a degenerative joint disease defined by the breakdown of cartilage with pain, stiffness, and swelling. An inflammatory process could be involved during the progression, and S100A8/A9 is considered a hallmark cytokine. With Lower Body Positive Pressure (LBPP) anti-gravity treadmill exercise, knee OA patients can walk with normal gait. Creatine monohydrate supplementation can decrease inflammation and improve the muscle strength. The central hypotheses stated was: inflammation associated with knee OA is related to serum S100A8/A9 level. The aims of this study focused on the effect of interventions and the level of serum S100A8/A9. Twenty-six (26) overweight participants with a mean age of 57 years were randomized into LBPP exercise, creatine supplementation, and control groups. KOOS scores, BMI, ROM, pain VAS score, and serum biomarkers were assessed. Statistical analysis indicated LBPP and Creatine could help to improve the function and disability. However the biomarkers were in normal range and not correlated to interventions.