The utility and application of non-invasive fluorescent imaging in murine models of allergic asthma
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Date
2017
Authors
Lytwyn, Matthew
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Abstract
Allergic asthma is characterized by airway hyperresponsiveness and lung inflammation. To better understand disease pathophysiology, lung inflammation is monitored in animal models, and in this regard, non-invasive medical imaging is emerging for use in pre-clinical research. The primary aim of this project is to develop protocols using non-invasive fluorescent optical imaging to quantitate lung inflammation in response to allergic challenge in a murine model of asthma. Our studies show that in vivo optical imaging provides a meaningful, non-invasive measure of lung inflammation, including dye specific enzymatic activity such as for cathepsins, in murine models of allergic asthma. This approach is a new option for repeated measurements in individual animals for drug testing and development.
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Keywords
asthma, respirology, medical imaging, spectral imaging