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dc.contributor.supervisorFigley, Chase (Physiology and Pathophysiology) Kornelsen, Jennifer (Physiology and Pathophysiology)en_US
dc.contributor.authorSolar, Kevin Grant
dc.date.accessioned2017-08-29T18:11:47Z
dc.date.available2017-08-29T18:11:47Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/1993/32388
dc.description.abstractStructural connectivity (SC) describes the white matter pathways that provide the electrochemical basis of functional connectivity (FC: temporally-coherent brain activity amongst anatomically-distinct brain regions). Initial human SC-FC relationship studies using magnetic resonance imaging (MRI) were largely exploratory and used only anatomical brain parcellations (failing to account for functional network organization), and revealed that SC reliably predicts FC, but that FC does not appear to predict SC. The purpose of this thesis is to elucidate SC-FC coupling within resting state functional networks. Diffusion tensor and myelin water MRI were applied to measure SC, with resting state functional MRI to measure FC. I tested the strength of SC-FC relationships by linear correlation and regression analyses. This thesis provides novel empirical evidence for divergent and non-overlapping SC-FC coupling within resting state networks, and importantly reveals a few specific brain regions that appear to be disproportionally involved in SC-FC coupling.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStructural connectivityen_US
dc.subjectFunctional connectivityen_US
dc.subjectRich cluben_US
dc.subjectLarge-scale networken_US
dc.subjectMRIen_US
dc.subjectResting stateen_US
dc.subjectFunctional MRIen_US
dc.subjectDTIen_US
dc.subjectMWIen_US
dc.titleQuantitative functionally-defined relationships between structural and functional connectivity within the human brainen_US
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplinePhysiology and Pathophysiologyen_US
dc.contributor.examiningcommitteeStecina, Katinka (Physiology and Pathophysiology) Marotta, Jonathan (Psychology)en_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2017en_US


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