The Systemic Myokine Response to an Acute Bout of Blood Flow Restricted Exercise
Blood flow restricted resistance training (BFR-RT) is an emerging hypertrophy training modality. A complete profile of its mechanisms of action has yet to be elucidated. Cytokines are universal intercellular messengers. Recent research has begun to implicate certain cytokines (termed “myokines”) in skeletal muscle hypertrophy pathways; however, no research has been conducted on the systemic myokine response to BFR-RT. The appearance of systemic myokines interleukin-6 (IL-6), interleukin-15 (IL-15), and decorin were measured following acute bouts of low-intensity resistance training (LI-RT), BFR-RT, and high-intensity resistance training (HI-RT) in young males to determine if BFR-RT modifies the exercise-induced systemic myokine response. No measureable levels of IL-6 were observed during the project. No significant effects were observed for IL-15. A significant time but no condition or condition by time effect was observed for decorin. These findings suggest that BFR-RT does not modify the systemic myokine appearance of IL-6, IL-15, or decorin.