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dc.contributor.author Nicolle, LE
dc.contributor.author Bialkowska-Hobrzanska, H
dc.contributor.author Dyck, B
dc.contributor.author Sekla, L
dc.contributor.author Parker, S
dc.date.accessioned 2016-06-09T17:41:24Z
dc.date.available 2016-06-09T17:41:24Z
dc.date.issued 1994-1-1
dc.identifier.citation LE Nicolle, H Bialkowska-Hobrzanska, B Dyck, L Sekla, and S Parker, “Molecular Epidemiology of Legionella pneumophila Infection at a Canadian Tertiary Care Institution,” Canadian Journal of Infectious Diseases, vol. 5, no. 4, pp. 157-162, 1994. doi:10.1155/1994/924761
dc.identifier.uri http://dx.doi.org/10.1155/1994/924761
dc.identifier.uri http://hdl.handle.net/1993/31478
dc.description.abstract Objective: To characterize the molecular epidemiology of Legionella species infection at one Canadian tertiary care centre.Design: Twenty-eight clinical isolates and 12 environmental isolates obtained over a six-year period were analyzed by restriction fragment length polymorphism (rflp) of chromosomal dna. Isolates included 15 from 12 patients with hospital acquired illness and 13 from nine patients with community acquired infection.Results: One nosocomial strain was Legionella micdadei and one community strain was Legionella pneumophila serotype 6; all others were L pneumophila serotype 1. rflp typing revealed one clone for all cases of a 1985 single-ward outbreak and five of six nonoutbreak L pneumophila nosocomial cases. An rflp pattern identical or highly related to that of the nosocomial clonal type was noted among nine of 12 L pneumophila serotype 1 community isolates. The remaining three isolates had two related rflp patterns distinct from the institutional strain. The nosocomial and community strains were isolated from multiple institutional water samples in the institution. For the environmental isolates, monoclonal antibody typing was more discriminating than rflp typing: seven monoclonal antibody subtypes were distinguished among 12 environmental isolates comprising three distinct rflp patterns.Conclusions: Despite multiple L pneumophila serotype 1 strains isolated in the authors’ institutional water, a single clone of L pneumophila produced most disease. Community acquired disease was caused by a wider variety of strains.
dc.title Molecular Epidemiology of Legionella pneumophila Infection at a Canadian Tertiary Care Institution
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.date.updated 2016-06-07T07:04:11Z


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