Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population
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Date
2015-5-3
Authors
Hashemi, Mohammad
Yousefi, Javad
Hashemi, Seyed Mehdi
Amininia, Shadi
Ebrahimi, Mahboubeh
Taheri, Mohsen
Ghavami, Saeid
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Abstract
It has been suggested that genetic factors contribute to patients’ vulnerability to breast cancer (BC). The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that is known to bind to the products of the PDCD6 gene, which is involved in the apoptosis pathway. The aim of this case-control study is to investigate the relationship between the PDCD6IP 15 bp insertion/deletion (I/D) polymorphism (rs28381975) and BC risk in an Iranian population.
A total of 491 females, including 266 BC patients and 225 control subjects without cancer, were enrolled into the study. Our findings revealed that the PDCD6IP 15 bp I/D polymorphism decreased the risk of BC in codominant (, 95% –0.65, , I/D versus DD; , 95% –0.88, , I/I versus DD) and dominant (, 95% –0.63, , D/I + I/I versus D/D) tested inheritance models. Also, the PDCD6IP I allele significantly decreased the risk of BC (, 95% –0.78, ) compared to the D allele.
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Mohammad Hashemi, Javad Yousefi, Seyed Mehdi Hashemi, et al., “Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population,” Disease Markers, vol. 2015, Article ID 854621, 5 pages, 2015. doi:10.1155/2015/854621