Show simple item record Sethi, R Saini, HK Wang, X Elimban, V Babick, A Dhalla, NS 2007-10-05T15:50:26Z 2007-10-05T15:50:26Z 2006-07-31
dc.identifier.citation 0008-4212; CAN J PHYSIOL PHARMACOL, JUL 2006, vol. 84, no. 7, p.747 to 754. en
dc.description.abstract Although different experimental and clinical studies have revealed varying degrees of defects in beta-adrenoceptors (beta-ARs) during the development of heart failure, the mechanisms for differences in beta-AR signal transduction between the left (LV) and right ventricle (RV) are not understood. Because biochemical alterations in the myocardium depend on the stage of heart disease, this study was undertaken to assess the status of beta-ARs in the LV and RV at different stages of heart failure. Myocardial infarction was induced in rats by occluding the left coronary artery for 8 and 24 weeks. The beta-AR signal transduction was monitored by measuring beta(1)-AR density, the isoproterenol-induced positive inotropic effect, the increase in [Ca2+]i in cardiomyocytes, and the activation of adenylyl cyclase. The beta-AR signal transduction parameters in the 8- and 24-week failing LV were depressed, whereas the RV showed upregulation at 8 weeks and downregulation at 24 weeks of these mechanisms. These results suggest that beta-AR-mediated signal transduction in the LV and RV are differentially regulated and are dependent upon the stage of development of congestive heart failure due to myocardial infarction. en
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dc.language.iso en_US
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dc.rights info:eu-repo/semantics/restrictedAccess
dc.subject cardiac beta-adrenoceptors en
dc.subject congestive heart failure en
dc.subject cardiac hypertrophy en
dc.subject myocardial infarction en
dc.subject signal transduction en
dc.subject ADENYLYL-CYCLASE en
dc.subject VOLUME OVERLOAD en
dc.subject GENE-EXPRESSION en
dc.subject G-PROTEINS en
dc.title Differential changes in beta-adrenoceptor signal transduction in left and right ventricles of infarcted rats en
dc.status Peer reviewed en

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