• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • University of Manitoba Researchers
    • University of Manitoba Scholarship
    • View Item
    •   MSpace Home
    • University of Manitoba Researchers
    • University of Manitoba Scholarship
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Play-the-winner rule and adaptive designs of clinical trials

    Thumbnail
    View/Open
    IJMMS.2001.461254.xml (3.177Kb)
    IJMMS.2001.461254.pdf (103.5Kb)
    Date
    2000-1-1
    Author
    Wang, Xikui
    Pullman, Daryl
    Metadata
    Show full item record
    Abstract
    In another paper, we have argued that the traditional randomized design of clinical trials is ethically infeasible in desperate medical situations and adaptive designs are morally required. We have also argued that in such situations, the appropriate designs must satisfy what we call the Principle of interchangeability. In this statistics paper, we show that the statistical model of bandit processes satisfies this principle of interchangeability. Moreover, we demonstrate that when such a model is used as an adaptive design, the total regret of successes lost is smaller when compared with simple randomization. We illustrate the results by the simple deterministic play-the-winner design.
    URI
    http://hdl.handle.net/1993/23790
    DOI
    10.1155/S0161171201005750
    Collections
    • Faculty of Science Scholarly Works [209]
    • University of Manitoba Scholarship [1952]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV