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    Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants

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    Date
    2013-4-16
    Author
    Martinez, Stephanie E.
    Sayre, Casey L.
    Davies, Neal M.
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    Abstract
    3-Methoxypterostilbene is a naturally occurring stilbene with potential in the treatment of diabetes. The preclinical pharmacokinetics and pharmacodynamics of 3-methoxypterostilbene were evaluated in the present study. The right jugular veins of male Sprague-Dawley rats were cannulated. The rats were dosed 10 mg/kg or 100 mg/kg of 3-methoxypterostilbene intravenously (IV) or orally (PO), respectively. Serum and urine samples were analyzed using a previously validated reversed-phase HPLC method. Serum AUC, serum , urine , , and Vd for IV dosing were  μg/h/mL,  h,  h,  L/h/kg, and  L/kg, respectively (mean ± SEM, ) . Serum AUC, serum , urine , , and Vd for PO dosing were  μg/h/mL,  h,  h,  L/h/kg, and  L/kg, respectively (mean ± SEM, ). Bioavailability of the stilbene was determined to be 50.6%  ± 10.0%. A 3-methoxypterostilbene glucuronidated metabolite was detected in both serum and urine. 3-Methoxypterostilbene exhibited antidiabetic activity including -glucosidase and -amylase inhibition as well as concentration-dependent antioxidant capacity similar to resveratrol. 3-Methoxypterostilbene also exhibited anti-inflammatory activity. 3-Methoxypterostilbene appears to be a bioactive compound and may be useful in reducing postprandial hyperglycemia.
    URI
    http://hdl.handle.net/1993/23771
    DOI
    10.1155/2013/261468
    Collections
    • Rady Faculty of Health Sciences Scholarly Works [1296]
    • University of Manitoba Scholarship [1952]

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