• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Role of protein tyrosine phosphorylation in chronic lymphocytic leukemia cell apoptosis

    Thumbnail
    View/Open
    MQ53138.pdf (5.702Mb)
    Date
    2000-10-01
    Author
    Cheng, Keding
    Metadata
    Show full item record
    Abstract
    Chronic lymphocytic leukemia (CLL) is a malignant disorder characterized by the proliferation and accumulation of mature appearing, though dysfunctional lymphocytes. The malignant lymphocytes infiltrate the bone marrow, lymph nodes, liver and spleen, resulting in enlargement of these organs and in bone marrow failure. In the present study, we investigated the role of tyrosine phosphorylation in CLL cell apoptosis. A cell line (WSU-CLL) derived from a CLL patient and the lymphocytes from several CLL patients and healthy volunteers were used to explore the role of protein tyrosine phosphorylation and its related signaling. Since tyrosine phosphorylation is important in lymphocyte signaling, including cell proliferation, differentiation and apoptosis, defects in tyrosine phosphorylation may contribute to the clonal expansion of this neoplasm. Tyrosine phosphorylation is maintained by a balance between the activities of the protein tyrosine kinases and phosphatases. We hypothesized that the inhibition of protein tyrosine phosphatase by vanadate would increase protein tyrosine phosphorylation and apoptosis in CLL cells. (Abstract shortened by UMI.)
    URI
    http://hdl.handle.net/1993/2353
    Collections
    • FGS - Electronic Theses and Practica [25527]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV