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Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)

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dc.contributor.author Chow, Benjamin JW
dc.contributor.author Green, Rachel E
dc.contributor.author Coyle, Doug
dc.contributor.author Laine, Mika
dc.contributor.author Hanninen, Helena
dc.contributor.author Leskinen, Hanna
dc.contributor.author Rajda, Miroslav
dc.contributor.author Larose, Eric
dc.contributor.author Hartikainen, Juha
dc.contributor.author Hedman, Marja
dc.contributor.author Mielniczuk, Lisa
dc.contributor.author O’Meara, Eileen
dc.contributor.author deKemp, Robert A
dc.contributor.author Klein, Ran
dc.contributor.author Paterson, Ian
dc.contributor.author White, James A
dc.contributor.author Yla-Herttuala, Seppo
dc.contributor.author Leber, Alex
dc.contributor.author Tandon, Vikas
dc.contributor.author Lee, Ting
dc.contributor.author Al-Hesayen, Abdul
dc.contributor.author Hessian, Renee
dc.contributor.author Dowsley, Taylor
dc.contributor.author Kass, Malek
dc.contributor.author Kelly, Cathy
dc.contributor.author Garrard, Linda
dc.contributor.author Tardif, Jean-Claude
dc.contributor.author Knuuti, Juhani
dc.contributor.author Beanlands, Rob S
dc.contributor.author Wells, George A
dc.contributor.author on behalf of the IMAGE-HF Investigators
dc.date.accessioned 2014-04-05T12:29:58Z
dc.date.available 2014-04-05T12:29:58Z
dc.date.issued 2013-12-26
dc.identifier.citation Trials. 2013 Dec 26;14(1):443
dc.identifier.uri http://hdl.handle.net/1993/23410
dc.description.abstract Abstract Background The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for coronary artery disease (CAD) and has been demonstrated to have prognostic value. Whether or not CTA can be used in HF patients is unknown. Acknowledging the aging population, the growing prevalence of HF and the increasing financial burden of healthcare, we need to identify non-invasive diagnostic tests that are available, safe, accurate and cost-effective. Methods/Design The proposed study aims to provide insight into the efficacy of CTA in HF patients. A multicenter randomized controlled trial will enroll 250 HF patients requiring coronary anatomical definition. Enrolled patients will be randomized to either CTA or ICA (n = 125 per group) as the first test to define coronary anatomy. The primary outcomes will be collected to determine downstream resource utilization. Secondary outcomes will include the composite clinical events and major adverse cardiac events. In addition, the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA. It is expected that CTA will be a more cost-effective strategy for diagnosis: yielding similar outcomes with fewer procedural risks and improved resource utilization. Trial registration ClinicalTrials.gov, NCT01283659 Team grant #CIF 99470
dc.rights info:eu-repo/semantics/openAccess
dc.title Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)
dc.type Journal Article
dc.type info:eu-repo/semantics/article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Benjamin JW Chow et al.; licensee BioMed Central Ltd.
dc.date.updated 2014-04-05T12:29:58Z
dc.identifier.doi http://dx.doi.org/10.1186/1745-6215-14-443


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