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HMG-CoA reductase inhibitors do not attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits

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dc.contributor.supervisor Arora, Rakesh C. (Surgery) Jassal, Davinder S. (Physiology) en_US
dc.contributor.author Kumar, Kanwal K.
dc.date.accessioned 2013-01-17T14:23:09Z
dc.date.available 2013-01-17T14:23:09Z
dc.date.issued 2013-01-17
dc.identifier.uri http://hdl.handle.net/1993/14909
dc.description.abstract Evidence suggests that there is an immunological response of the recipient to xenograft bioprosthetic heart valves. Information on the impact of HMG-CoA reductase inhibitors (statins) and their anti-inflammatory properties on bioprosthetic valve failure remains limited. We sought to examine the efficacy of statin therapy in a rodent model of bioprosthetic valve implantation. To mimic the human scenario, fresh or glutaraldehyde-fixed aortic valve root conduits from Lewis rats or Hartley guinea pigs were microsurgically implanted intravascularly into the infra-renal aorta of Lewis rats. The syngeneic control group consisted of a fresh rat valve conduit implanted into a rat. The xenogeneic control group consisted of a glutaraldehyde-fixed guinea pig valve conduit implanted into a rat. Treatment groups consisted of xenogeneic groups treated with either daily steroids or statins. Overall, steroid treatment attenuated the inflammatory response observed within the xenogeneic glutaraldehyde-fixed valve conduits. Treatment with statins did not decrease this inflammatory response. en_US
dc.subject Cardiac Surgery en_US
dc.subject Bioprosthetic Valve en_US
dc.subject HMG-CoA reductase inhibitors en_US
dc.subject Statin en_US
dc.subject Inflammation en_US
dc.subject In vivo Rodent Model en_US
dc.title HMG-CoA reductase inhibitors do not attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits en_US
dc.degree.discipline Surgery en_US
dc.contributor.examiningcommittee Kardami, Elissavet (Human Anatomy & Cell Science) Freed, Darren H. (Surgery) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2013 en_US


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