Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds

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dc.contributor.authorRamprasath, Vanu R
dc.contributor.authorJenkins, David JA
dc.contributor.authorLamarche, Benoit
dc.contributor.authorKendall, Cyril WC
dc.contributor.authorFaulkner, Dorothea
dc.contributor.authorCermakova, Luba
dc.contributor.authorCouture, Patrick
dc.contributor.authorIreland, Chris
dc.contributor.authorAbdulnour, Shahad
dc.contributor.authorPatel, Darshna
dc.contributor.authorBashyam, Balachandran
dc.contributor.authorSrichaikul, Korbua
dc.contributor.authorde Souza, Russell J
dc.contributor.authorVidgen, Edward
dc.contributor.authorJosse, Robert G
dc.contributor.authorLeiter, Lawrence A
dc.contributor.authorConnelly, Philip W
dc.contributor.authorFrohlich, Jiri
dc.contributor.authorJones, Peter JH
dc.date.accessioned2014-11-13T21:04:22Z
dc.date.available2014-11-13T21:04:22Z
dc.date.issued2014-10-18
dc.date.updated2014-11-13T21:04:22Z
dc.description.abstractAbstract Background Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption. Objective The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins. Methods Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months. Results No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12:p = 0.045; week 24:p = 0.039) and routine (week 12:p = 0.031; week 24:p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels. Conclusion Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction. Trial registration clinicaltrials.gov Identifier: NCT00438425
dc.description.versionPeer Reviewed
dc.identifier.citationNutrition Journal. 2014 Oct 18;13(1):101
dc.identifier.doihttp://dx.doi.org/10.1186/1475-2891-13-101
dc.identifier.urihttp://hdl.handle.net/1993/28564
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderVanu R Ramprasath et al.; licensee BioMed Central Ltd.
dc.titleConsumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
dc.typeJournal Article
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