Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

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dc.contributor.authorChagla, Abdul H
dc.contributor.authorHii, John H
dc.contributor.authorHoban, Daryl J
dc.contributor.authorSimor, Andrew E
dc.contributor.authorFerro, Santiago
dc.contributor.authorWitwicki, Evelyn
dc.contributor.authorPoon, Ruby
dc.contributor.authorLow, Donald E
dc.date.accessioned2016-06-09T19:14:42Z
dc.date.available2016-06-09T19:14:42Z
dc.date.issued1992-1-1
dc.date.updated2016-06-07T07:05:24Z
dc.description.abstractThe in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.
dc.description.versionPeer Reviewed
dc.identifier.citationAbdul H Chagla, John H Hii, Daryl J Hoban, et al., “Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method,” Canadian Journal of Infectious Diseases, vol. 3, no. 5, pp. 231-234, 1992. doi:10.1155/1992/260839
dc.identifier.urihttp://dx.doi.org/10.1155/1992/260839
dc.identifier.urihttp://hdl.handle.net/1993/31488
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleComparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method
dc.typeJournal Article
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