Snoring sounds analysis: automatic detection, higher order statistics, and its application for sleep apnea diagnosis
| dc.contributor.author | Azarbarzin, Ali | |
| dc.contributor.examiningcommittee | Pawlak, Mirek (Electrical and Computer Engineering) Alfa, Attahiru S (Electrical and Computer Engineering) Bshouty, Zoheir (Internal Medicine) Malhotra, Atul (Harvard Medical School) | en_US |
| dc.contributor.supervisor | Moussavi, Zahra (Electrical and Computer Engineering) | en_US |
| dc.date.accessioned | 2012-10-24T15:46:52Z | |
| dc.date.available | 2012-10-24T15:46:52Z | |
| dc.date.issued | 2011 | en_US |
| dc.date.issued | 2012 | en_US |
| dc.degree.discipline | Electrical and Computer Engineering | en_US |
| dc.degree.level | Doctor of Philosophy (Ph.D.) | en_US |
| dc.description.abstract | Snoring is a highly prevalent disorder affecting 20-40% of adult population. Snoring is also a major indicative of obstructive sleep apnea (OSA). Despite the magnitude of effort, the acoustical properties of snoring in relation to physiological states are not yet known. This thesis explores statistical properties of snoring sounds and their association with OSA. First, an unsupervised technique was developed to automatically extract the snoring sound segments from the lengthy recordings of respiratory sounds. This technique was tested over 5665 snoring sound segments of 30 participants and the detection accuracy of 98.6% was obtained. Second, the relationship between anthropometric parameters of snorers with different degrees of obstruction and their snoring sounds’ statistical characteristics was investigated. Snoring sounds are non-Gaussian in nature; thus second order statistical methods such as power spectral analysis would be inadequate to extract information from snoring sounds. Therefore, higher order statistical features, in addition to the second order ones, were extracted. Third, the variability of snoring sound segments within and between 57 snorers with and without OSA was investigated. It was found that the sound characteristics of non-apneic (when there is no apneic event), hypopneic (when there is hypopnea), and post-apneic (after apnea) snoring events were significantly different. Then, this variability of snoring sounds was used as a signature to discriminate the non-OSA snorers from OSA snorers. The accuracy was found to be 96.4%. Finally, it was observed that some snorers formed distinct clusters of snoring sounds in a multidimensional feature space. Hence, using Polysomnography (PSG) information, the dependency of snoring sounds on body position, sleep stage, and blood oxygen level was investigated. It was found that all the three variables affected snoring sounds. However, body position was found to have the highest effect on the characteristics of snoring sounds. In conclusion, snoring sounds analysis offers valuable information on the upper airway physiological state and pathology. Thus, snoring sound analysis may further find its use in determining the exact state and location of obstruction. | en_US |
| dc.description.note | February 2013 | en_US |
| dc.identifier.citation | A.Azarbarzin and Z.Moussavi, "Automatic and Unsupervised Snore Sound Extraction from Respiratory Sound Signals," IEEE Trans Biomed Eng. Vol 58, pp. 1156-1162, 2011, DOI:10.1109/TBME.2010.2061846. | en_US |
| dc.identifier.citation | A.Azarbarzin and Z.Moussavi, "Snoring Sounds’ Statistical Characteristics Depend on Anthropometric Parameters," Journal of Biomedical Science and Engineering, Vol 5, pp. 245-254, 2012, DOI: 10.4236/jbise.2012.55031. | en_US |
| dc.identifier.citation | A.Azarbarzin and Z.Moussavi, "Snoring Sounds Variability as a Signature of Obstructive Sleep Apnea," Journal of Medical Engineering & Physics, In press, 2012, DOI:10.1016/j.medengphy.2012.06.013. | en_US |
| dc.identifier.citation | A.Azarbarzin and Z.Moussavi, "Snoring Sounds Intra-Subject Variability," Submitted to Medical and Biological Engineering and Computing, 2012. | en_US |
| dc.identifier.citation | A.Azarbarzin and Z.Moussavi, "Nonlinear properties of snoring sounds," Proc. ICASSP, Prague, pp. 4316-19, 2011. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/9593 | |
| dc.language.iso | eng | en_US |
| dc.publisher | IEEE | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | open access | en_US |
| dc.subject | Snoring sounds acoustics | en_US |
| dc.subject | Sleep apnea | en_US |
| dc.subject | Statistical properties | en_US |
| dc.subject | Detection | en_US |
| dc.subject | Classification | en_US |
| dc.subject | Intra-subject variation | en_US |
| dc.title | Snoring sounds analysis: automatic detection, higher order statistics, and its application for sleep apnea diagnosis | en_US |
| dc.type | doctoral thesis | en_US |