Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans
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Date
2003-03-31
Authors
Cow, C
Leung, C
Charlton, JL
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Abstract
A practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1,2-dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, e.g., 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus measured.
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Keywords
lignan, Stobbe, arylnaphthalene, antiviral, 1-ARYLNAPHTHALENE LIGNAN, NEOLIGNANS, LACTONES, INHIBITOR
Citation
0008-4042; CAN J CHEM, MAY 2000, vol. 78, no.5, p.553 to 561.