Retrograde cardioplegia, effec s of coronary venous perfusion on myocardial energy metabolism, contractile function and myocardial perfusion in neonatal hearts
| dc.contributor.author | Oriaku, Godwin I. | en_US |
| dc.date.accessioned | 2007-05-15T19:06:25Z | |
| dc.date.available | 2007-05-15T19:06:25Z | |
| dc.date.issued | 1998-06-01T00:00:00Z | en_US |
| dc.degree.discipline | Physiology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Objective. This study tested the hypothesis that a heart maintained in arrest by retrograde cardioplegia (RC) can recover metabolic and contractile function to a level comparable to that of antegrade cardioplegia (AC). Methods. Isolated Langendorff piglet hearts were subjected a protocol consisting of 30 minutes of control perfusion, 45 minutes of arrest, and 30 minutes of reperfusion. During the control and reperfusion periods, the hearts were pelfused using Krebs-Henseleit (K-H) solution. Cardioplegic arrest was induced with two minutes of AC. Arrest was maintained for 43 minutes with continuous RC in group 1. The hearts in roup 2 were subjected to 45 minutes of continuous AC. Myocardial energy metabolism and contractile function in the two groups were compared by assessing energy metabolites using $\sp{31}$P MR spectroscopy and determining myocardial O$\sb2$ consumption (MVO$\sb2)$ and measuring intraventricular pressure. (Abstract shortened by UMI.) | en_US |
| dc.format.extent | 5449891 bytes | |
| dc.format.extent | 184 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | text/plain | |
| dc.identifier.uri | http://hdl.handle.net/1993/1231 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.title | Retrograde cardioplegia, effec s of coronary venous perfusion on myocardial energy metabolism, contractile function and myocardial perfusion in neonatal hearts | en_US |
| dc.type | master thesis | en_US |