ABSTRACT Two experiments were conducted to determine the net energy (NE) of wheat-corn distillers dried grains with solubles (wcDDGS) using the comparative slaughter (CS), the indirect calorimetry (IC) and the chemical composition (CH) methods. Based on the CS method, NE values of 2,407, and 2,424 kcal/kg DM were obtained for wcDDGS included at 15% and 30%, respectively. For the IC method, the NE values of 2,407, and 2,403 kcal/kg DM were obtained for wcDDGS included at 15% and 30%, respectively; corresponding values for the CH method were 2,536 and 2,197 kcal/kg DM, respectively. It is concluded that NE value of wcDDGS ranges from 2,367 kcal/kg DM to 2,416 kcal/kg DM depending on the method used. As the values obtained from the various methods were not different, the average NE value for the wcDDGS evaluated was 2,396 ± 25.71 kcal/kg DM.