Proactive immunity and vaccination against cutaneous leishmaniasis

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dc.contributor.authorUzonna, Jude
dc.contributor.authorOkwor, Ifeoma
dc.contributor.authorMou, Zhirong
dc.contributor.authorDong, Liu
dc.date.accessioned2014-06-18T20:00:08Z
dc.date.available2014-06-18T20:00:08Z
dc.date.issued2012-05-29
dc.description.abstractAlthough a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity,particularly those associated with secondary (memory)immunity. Such an understanding is critically important for designing safe, effective, and universally acceptable vaccine against the disease. Here we review the literature on the correlate of protective anti- Leishmania immunity and vaccination strategies against leishmaniasis with a bias emphasis on experimental cutaneous leishmaniasien_US
dc.description.sponsorshipThis work was supported by grants from the Canadian Institutes of Health Research (CIHR) and Manitoba Health Research Council (MHRC). IO is supported by the Doctoral Award and CIHR International Infectious Disease and Global Health Training Program.en_US
dc.identifier.citationUzonna, J., Okwor, I., Mou, Z., Liu, D. Protective immunity and vaccination against cutaneous leishmaniasis. (2012) Front. Immun. 3, 1-13en_US
dc.identifier.doihttp://dx.doi.org/10.3389/fimmu.2012.00128
dc.identifier.urihttp://hdl.handle.net/1993/23637
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsopen accessen_US
dc.subjectCutaneous leishmaniasisen_US
dc.subjectInnate immunityen_US
dc.subjectAdaptive immunityen_US
dc.subjectInfection-induced resistanceen_US
dc.subjectVaccineen_US
dc.subjectVaccinationen_US
dc.titleProactive immunity and vaccination against cutaneous leishmaniasisen_US
dc.typeArticleen_US
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