Early detection of broken hearts in cancer: Bevacizumab and Sunitinib mediated cardiotoxicity

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dc.contributor.authorBordun, Kimberly-Ann
dc.contributor.examiningcommitteeDuhamel, Todd (Physiology) Ravandi, Amir (Physiology) Wigle, Jeff (Biochemistry and Medical Genetics)en_US
dc.contributor.supervisorJassal, Davinder (Physiology) Singal, Pawan K.(Physiology)en_US
dc.date.accessioned2014-08-26T17:05:25Z
dc.date.available2014-08-26T17:05:25Z
dc.date.issued2014-08-26
dc.degree.disciplinePhysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractBackground: Although Bevacizumab (BVZ) and Sunitinib (SNT) prolong survival in cancer patients, an unanticipated side-effect is cardiotoxicity. Early indices of left ventricular (LV) systolic dysfunction would be useful to address the cardiac safety of anti-cancer drugs. Objective: Whether cardiac biomarkers, tissue velocity imaging (TVI), and/or strain rate (SR) can detect early cardiac dysfunction. Methods: A total of 95 C57Bl/6 mice received one of the following drug regimens: i) 0.9% saline; ii) BVZ; or iii) SNT and followed for 14 days. Serial blood pressure, high sensitivity troponin I (hsTnI), and echocardiography were performed. Results: BVZ- and SNT-treated mice demonstrated an increase in mean arterial blood pressure, hsTnI, cardiac apoptosis, and loss of cell integrity. TVI and SR values confirmed early LV systolic dysfunction at day 8, compared to conventional LVEF at day 13. Conclusions: Novel imaging techniques can detect early LV systolic dysfunction in a model of drug-mediated cardiomyopathy.en_US
dc.description.noteOctober 2014en_US
dc.identifier.urihttp://hdl.handle.net/1993/23884
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectCanceren_US
dc.subjectCardiomyopathyen_US
dc.subjectBevacizumaben_US
dc.subjectSunitiniben_US
dc.subjectCardiotoxicityen_US
dc.subjectEchocardiographyen_US
dc.subjectTissue velocity imagingen_US
dc.subjectBiomarkersen_US
dc.subjectHemodynamicsen_US
dc.subjectOxidative stressen_US
dc.titleEarly detection of broken hearts in cancer: Bevacizumab and Sunitinib mediated cardiotoxicityen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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