An anthropological approach to immunogenetic variation in Manitoba First Nation populations: implications for tuberculosis

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dc.contributor.authorDecter, Kate Leah Una
dc.contributor.examiningcommitteeHoppa, Robert (Anthropology) Burke, Stacie (Anthropology) Herring, Ann (Anthropology, McMaster University)en_US
dc.contributor.supervisorLarcombe, Linda (Anthropology)en_US
dc.date.accessioned2013-09-03T14:05:31Z
dc.date.available2013-09-03T14:05:31Z
dc.date.issued2013-09-03
dc.degree.disciplineAnthropologyen_US
dc.degree.levelMaster of Arts (M.A.)en_US
dc.description.abstractThis research investigated immunogenetic variability and explored how genetics and the unique histories of First Nations may contribute to differential resistance and/or susceptibility to tuberculosis. With the support of First Nations communities, DNA samples were collected from Dene, Saulteaux, Cree and Caucasian cohorts within Manitoba. Single nucleotide polymorphisms (SNPs) in the cytokines promoter region of IL-12 (rs3212227) and in genes encoding the TLR2 (rs5743708)and TLR4 (rs4986790&4986791) were typed using PCR-RFLP analysis. Compared with the Caucasian and Saulteaux populations, the Dene and Cree were found to have a significantly higher frequency of SNPs associated with IL-12 low expression, while variation within TLRs was not statistically significant. The lower production of IL-12 has been associated with a down-regulated Th1 immune response, which is essential for the containment of Mycobacterium tuberculosis. First Nations have unique cultural, political and historical identities and the contemporary immunogenetic profiles are likely a reflection of these histories.en_US
dc.description.noteOctober 2013en_US
dc.identifier.urihttp://hdl.handle.net/1993/22131
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectHealthen_US
dc.subjectAboriginalen_US
dc.subjectTuberculosisen_US
dc.subjectImmunogeneticen_US
dc.titleAn anthropological approach to immunogenetic variation in Manitoba First Nation populations: implications for tuberculosisen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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