Negative regulation of PGC-1α by NF-κB
| dc.contributor.author | Blant, Alexandra | |
| dc.contributor.examiningcommittee | Duhamel, Todd (Kinesiology and Recreation Management) Singal, Pawan (Physiology) Kirshenbaum, Lorrie (Physiology) | en_US |
| dc.contributor.supervisor | Czubryt, Michael (Physiology) | en_US |
| dc.date.accessioned | 2014-01-10T19:37:59Z | |
| dc.date.available | 2014-01-10T19:37:59Z | |
| dc.date.issued | 2014-01-10 | |
| dc.degree.discipline | Physiology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | The normal adult heart prefers fatty acids as an energy substrate. In the case of heart failure, the heart switches its preference from fatty acids to glucose, adopting a pattern similar to fetal metabolism. PGC-1α is heavily involved in the shift towards glucose oxidation. p65, which belongs to the NF-κB transcription factor family is another crucial molecule involved in maintaining cardiac homeostasis. There is a substantial amount of evidence suggesting that PGC-1α and NF-κB directly interact, thereby connecting metabolic and inflammatory processes. Dysregulation of either PGC-1α or NF-κB signalling correlates to many diseases including heart disease. In this study, we provide further evidence that the NF-κB family has the ability to repress PGC-1α. We also show that the PGC-1α promoter contains a p65 binding site through which p65 imparts control on the PGC-1α gene. Metabolic homeostasis and inflammation pathways are closely linked and play crucial roles in heart dysfunction. | en_US |
| dc.description.note | February 2014 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/23146 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | heart disease | en_US |
| dc.subject | PGC-1α promoter | en_US |
| dc.subject | NF-κB | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | fatty acid metabolism | en_US |
| dc.subject | metabolism and inflammation | en_US |
| dc.subject | fetal metabolic profile | en_US |
| dc.subject | cardiac homeostasis | en_US |
| dc.title | Negative regulation of PGC-1α by NF-κB | en_US |
| dc.type | master thesis | en_US |