The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease

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dc.contributor.authorXi, Shengyan
dc.contributor.authorYue, Lifeng
dc.contributor.authorShi, Mengmeng
dc.contributor.authorPeng, Ying
dc.contributor.authorXu, Yangxinzi
dc.contributor.authorWang, Xinrong
dc.contributor.authorLi, Qian
dc.contributor.authorKang, Zhijun
dc.contributor.authorLi, Hanjing
dc.contributor.authorWang, Yanhui
dc.date.accessioned2016-05-16T14:00:23Z
dc.date.available2016-05-16T14:00:23Z
dc.date.issued2016-5-11
dc.date.updated2016-05-14T07:00:47Z
dc.description.abstractChronic liver disease is one of the most common diseases that threaten human health. Effective treatment is still lacking in western medicine. Semen Persicae (Taoren) and Flos Carthami (Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber. The aim of our study is to investigate the potential mechanisms of Taoren-Honghua Herb Pair (THHP) in murine model of chronic liver disease caused by Carbon Tetrachloride (CCl4). Mice were randomly divided into seven groups: (1) blank, (2) model, (3) control (colchicine, 0.1 mg/kg), (4) THHP (5.53, 2.67, and 1.33 g/kg), and (5) Tao Hong Siwu Decoction (THSWD) (8.50 g/kg). Histological change and microvessels density were examined by microscopy. Hepatic function, serum fibrosis related factors, and hepatic vascular endothelial growth factor (VEGF) were measured with ELISA. VEGF, kinase insert domain-containing receptor (KDR), Flt-1, and Akt mRNA expression in hepatic tissue were determined with PCR. Tissues of Akt, pAkt, KDR, and Flt-1 were measured with western blotting. Data from this study showed that THHP improved hepatic function and restrained the hepatic inflammation and fibrosis. Its role in inhibiting pathological angiogenesis and hepatic fibrogenesis may be through affecting the angiogenesis-associated VEGF and its upstream and downstream signaling pathways.
dc.description.versionPeer Reviewed
dc.identifier.citationShengyan Xi, Lifeng Yue, Mengmeng Shi, et al., “The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 2974256, 11 pages, 2016. doi:10.1155/2016/2974256
dc.identifier.urihttp://dx.doi.org/10.1155/2016/2974256
dc.identifier.urihttp://hdl.handle.net/1993/31299
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2016 Shengyan Xi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleThe Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease
dc.typeJournal Article
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