The impact of mean arterial pressure on functional outcome post-acute spinal cord injury: a systematic review of animal models and human clinical data
| dc.contributor.author | Sabit, Behzad | |
| dc.contributor.examiningcommittee | Srinathan, Sadeesh (Surgery) Kaufmann, Anthony (Surgery) Schmidt, Brian (Internal Medicine) | en_US |
| dc.contributor.supervisor | Berrington, Neil (Surgery) | en_US |
| dc.date.accessioned | 2017-09-13T17:33:04Z | |
| dc.date.available | 2017-09-13T17:33:04Z | |
| dc.date.issued | 2016 | en_US |
| dc.degree.discipline | Surgery | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | The occurrence of hypotension has been shown to be associated with worse outcomes after traumatic injury, including severe head injury. To our knowledge, a prospective controlled assessment of the effects of hypotension on acute spinal cord injury (ASCI) in humans has not been performed. Animal models of ASCI have been created in laboratory and data is extrapolated to the clinical setting, suggesting that hypotension contributes to secondary injury after ASCI by reducing spinal cord blood flow and perfusion.Given the lack of conclusive evidence on the topic, we set out to perform a comprehensive review of the pertinent evidence, first of the animal models on which the current guidelines are based, followed by a review of the human clinical data which is available. The goal was to assess the merit of the current guidelines and ascertain the correct target MAP immediately after ASCI as well as the duration for which this MAP must be targeted. | en_US |
| dc.description.note | October 2017 | en_US |
| dc.identifier.citation | “The Impact of Mean Arterial Pressure on Functional Outcome Post Trauma-Related Acute Spinal Cord Injury: A Scoping Systematic Review of the Human Literature” J Intensive Care Med. 2016 Oct 12 | en_US |
| dc.identifier.citation | “The Impact of Mean Arterial Pressure on Functional Outcome Post-Acute Spinal Cord Injury: A Scoping Systematic Review of Animal Models” J Neurotrauma. 2016 Oct 27. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32596 | |
| dc.language.iso | eng | en_US |
| dc.publisher | Journal of intensive care medicine, Journal of neurotrauma | en_US |
| dc.rights | open access | en_US |
| dc.subject | spinal cord injury | en_US |
| dc.subject | mean arterial pressure | en_US |
| dc.subject | directed therapy | en_US |
| dc.title | The impact of mean arterial pressure on functional outcome post-acute spinal cord injury: a systematic review of animal models and human clinical data | en_US |
| dc.type | master thesis | en_US |