A bioavailable form of curcumin suppresses cationic host defence peptides cathelicidin and calprotectin in a murine model of collagen-induced arthritis

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dc.contributor.authorHemshekhar, Mahadevappa
dc.contributor.authorLloyd, Dylan
dc.contributor.authorEl-Gabalawy, Hani
dc.contributor.authorMookherjee, Neeloffer
dc.date.accessioned2023-11-30T16:58:32Z
dc.date.available2023-11-30T16:58:32Z
dc.date.issued2023-09-04
dc.date.updated2023-11-03T09:17:53Z
dc.description.abstractCurcumin, a component of the South-Asian spice turmeric, elicits anti-inflammatory functions. We have previously demonstrated that a highly bioavailable formulation of cucurmin, Cureit/Acumin™ (CUR), can suppress disease onset and severity, in a collagen-induced arthritis (CIA) mouse model. In a previous study, we have also shown that the abundance of antimicrobial host defence peptides, specifically cathelicidin (CRAMP) and calprotectin (S100A8 and S100A9), is significantly increased in the joint tissues of CIA mice. Elevated levels of cathelicidin and calprotectin have been associated with the pathogenesis of rheumatoid arthritis. Therefore, in this study, we examined the effect CUR administration on the abundance of cathelicidin and calprotectin in the joints, in a CIA mouse model. Here, we demonstrate that daily oral administration of CUR significantly reduces the elevated levels of CRAMP and calprotectin to baseline in the joints of CIA mice. We also show a linear correlation between the abundance of these peptides in the joints with serum inflammatory cytokines TNFα, IFNγ, and MCP-1. Overall, our results suggest that oral administration of a bioavailable CUR can suppress cathelicidin and calprotectin in the joints and regulate both local (joints) and systemic (serum) inflammation, in inflammatory arthritis.
dc.identifier.citationArthritis Research & Therapy. 2023 Sep 04;25(1):161
dc.identifier.doi10.1186/s13075-023-03148-x
dc.identifier.urihttp://hdl.handle.net/1993/37832
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rightsopen accessen_US
dc.rights.holderBioMed Central Ltd., part of Springer Nature
dc.subjectarthritis
dc.subjectinflammation
dc.subjecthost defence peptides
dc.subjectcurcumin
dc.subjectcathelicidin
dc.subjectcalprotectin
dc.titleA bioavailable form of curcumin suppresses cationic host defence peptides cathelicidin and calprotectin in a murine model of collagen-induced arthritis
dc.typeletter
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Internal Medicine
oaire.citation.issue161
oaire.citation.titleArthritis Research & Therapy
oaire.citation.volume25
project.funder.identifierhttps://doi.org/10.13039/501100000024
project.funder.nameCanadian Institutes of Health Research
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