Vitamin D Status and Bone Density in Recently Diagnosed Inflammatory Bowel Disease: The Manitoba IBD Cohort Study

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dc.contributor.authorLeslie, William
dc.contributor.authorMiller, Norine
dc.contributor.authorRogala, Linda
dc.contributor.authorBernstein, Charles N.
dc.date.accessioned2015-05-11T20:21:30Z
dc.date.available2015-05-11T20:21:30Z
dc.date.issued2008-06
dc.description.abstractOBJECTIVES: Bone mineral density (BMD) is usually normal at the time of inflammatory bowel disease (IBD) diagnosis. The purpose of this study was to evaluate the role of vitamin D metabolism in recently diagnosed IBD. METHODS: Adult subjects with recently diagnosed IBD (median 4 yr) were recruited from the University of Manitoba IBD Research Registry into the Manitoba IBD Cohort Study. Baseline BMD and serum 25-hydroxy vitamin D (25OHD) were measured in a nested subgroup of 101 subjects of whom 94 had repeat BMD measurements 2.3 +/- 0.3 yr later. RESULTS: Only a minority (22 [21.8%]) of recently diagnosed IBD participants had optimal serum 25OHD levels (75 nmol/L or greater). Serum 25OHD was positively correlated with baseline BMD for the lumbar spine, total hip, and total body (all P < 0.05). MANOVA confirmed significant between-group differences in baseline T-scores when vitamin D status was categorized according to serum 25OHD quartile (P < 0.05). Gain in total body BMD between the baseline and follow-up DXA scans was positively correlated with 25OHD (r = 0.20, P < 0.05). CONCLUSIONS: Poorer vitamin D status correlates with lower baseline BMD at all measurement sites and better vitamin D status is correlated with a gain in total body BMD. Early optimization of vitamin D may play an important role in preventing IBD-related bone disease.en_US
dc.identifier.citationAm J Gastroenterol. 2008 Jun;103(6):1451-9en_US
dc.identifier.doi10.1111/j.1572-0241.2007.01753.x
dc.identifier.urihttp://hdl.handle.net/1993/30436
dc.language.isoengen_US
dc.publisherAmerican Journal Gastroenterologyen_US
dc.relation.ispartofseries103(6);1451-9
dc.rightsopen accessen_US
dc.subjectVitamin Den_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectBernsteinen_US
dc.titleVitamin D Status and Bone Density in Recently Diagnosed Inflammatory Bowel Disease: The Manitoba IBD Cohort Studyen_US
dc.typeArticleen_US
dc.typeDataseten_US
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