Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines

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dc.contributor.authorJohnston, Bradley C.
dc.contributor.authorZeraatkar, Dena
dc.contributor.authorSteen, Jeremy
dc.contributor.authorde Jauregui, Diego R. F.
dc.contributor.authorZhu, Hongfei
dc.contributor.authorSun, Mingyao
dc.contributor.authorCooper, Matthew
dc.contributor.authorMaraj, Malgorzata
dc.contributor.authorProkop-Dorner, Anna
dc.contributor.authorReyes, Boris C.
dc.contributor.authorValli, Claudia
dc.contributor.authorStorman, Dawid
dc.contributor.authorKaram, Giorgio
dc.contributor.authorZajac, Joanna
dc.contributor.authorGe, Long
dc.contributor.authorSwierz, Mateusz J.
dc.contributor.authorGhosh, Nirjhar
dc.contributor.authorVernooij, Robin W. M.
dc.contributor.authorChang, Yaping
dc.contributor.authorZhao, Yunli
dc.contributor.authorThabane, Lehana
dc.contributor.authorGuyatt, Gordon H.
dc.contributor.authorAlonso-Coello, Pablo
dc.contributor.authorHooper, Lee
dc.contributor.authorBala, Malgorzata M.
dc.date.accessioned2023-05-01T15:48:30Z
dc.date.available2023-05-01T15:48:30Z
dc.date.issued2023-03-14
dc.date.updated2023-04-04T17:42:30Z
dc.description.abstractAbstract Background The health effects of dietary fats are a controversial issue on which experts and authoritative organizations have often disagreed. Care providers, guideline developers, policy-makers, and researchers use systematic reviews to advise patients and members of the public on optimal dietary habits, and to formulate public health recommendations and policies. Existing reviews, however, have serious limitations that impede optimal dietary fat recommendations, such as a lack of focus on outcomes important to people, substantial risk of bias (RoB) issues, ignoring absolute estimates of effects together with comprehensive assessments of the certainty of the estimates for all outcomes. Objective We therefore propose a methodologically innovative systematic review using direct and indirect evidence on diet and food-based fats (i.e., reduction or replacement of saturated fat with monounsaturated or polyunsaturated fat, or carbohydrates or protein) and the risk of important health outcomes. Methods We will collaborate with an experienced research librarian to search MEDLINE, EMBASE, CINAHL, and the Cochrane Database of Systematic Reviews (CDSR) for randomized clinical trials (RCTs) addressing saturated fat and our health outcomes of interest. In duplicate, we will screen, extract results from primary studies, assess their RoB, conduct de novo meta-analyses and/or network meta-analysis, assess the impact of missing outcome data on meta-analyses, present absolute effect estimates, and assess the certainty of evidence for each outcome using the GRADE contextualized approach. Our work will inform recommendations on saturated fat based on international standards for reporting systematic reviews and guidelines. Conclusion Our systematic review and meta-analysis will provide the most comprehensive and rigorous summary of the evidence addressing the relationship between saturated fat modification for people-important health outcomes. The evidence from this review will be used to inform public health nutrition guidelines. Trial registration PROSPERO Registration: CRD42023387377 .en_US
dc.identifier.citationSystematic Reviews. 2023 Mar 14;12(1):39
dc.identifier.citationSystematic Reviews. 2023 Mar 14;12(1):39
dc.identifier.urihttps://doi.org/10.1186/s13643-023-02209-1
dc.identifier.urihttp://hdl.handle.net/1993/37319
dc.language.isoengen_US
dc.language.rfc3066en
dc.publisherBioMed Central (BMC)en_US
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.titleSaturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelinesen_US
dc.typejournal articleen_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Internal Medicineen_US
oaire.citation.issue1en_US
oaire.citation.startPage39en_US
oaire.citation.titleSystematic Reviewsen_US
oaire.citation.volume12en_US
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