Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice

dc.contributor.authorVerbout, Norah G.
dc.contributor.authorBenedito, Leandro
dc.contributor.authorWilliams, Alison S.
dc.contributor.authorKasahara, David I.
dc.contributor.authorWurmbrand, Allison P.
dc.contributor.authorSi, Huiqing
dc.contributor.authorHalayko, Andrew J.
dc.contributor.authorHug, Christopher
dc.contributor.authorShore, Stephanie A.
dc.date.accessioned2014-08-14T06:51:28Z
dc.date.available2014-08-14T06:51:28Z
dc.date.issued2013-6-4
dc.date.updated2014-08-14T06:51:28Z
dc.description.abstractObesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of adiponectin would attenuate allergic airways inflammation and mucous hyperplasia in mice. To test this hypothesis, we used mice overexpressing adiponectin (Adipo Tg). Adipo Tg mice had marked increases in both serum adiponectin and bronchoalveolar lavage (BAL) fluid adiponectin. Both acute and chronic ovalbumin (OVA) sensitization and challenge protocols were used. In both protocols, OVA-induced increases in total BAL cells were attenuated in Adipo Tg versus WT mice. In the acute protocol, OVA-induced increases in several IL-13 dependent genes were attenuated in Adipo Tg versus WT mice, even though IL-13 per se was not affected. With chronic exposure, though OVA-induced increases in goblet cells numbers per millimeter of basement membrane were greater in Adipo Tg versus WT mice, mRNA abundance of mucous genes in lungs was not different. Also, adiponectin overexpression did not induce M2 polarization in alveolar macrophages. Our results indicate that adiponectin protects against allergen-induced inflammatory cell recruitment to the airspaces, but not development of goblet cell hyperplasia.
dc.description.versionPeer Reviewed
dc.identifier.citationNorah G. Verbout, Leandro Benedito, Alison S. Williams, et al., “Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice,” Journal of Allergy, vol. 2013, Article ID 349520, 13 pages, 2013. doi:10.1155/2013/349520
dc.identifier.doihttp://dx.doi.org/10.1155/2013/349520
dc.identifier.urihttp://hdl.handle.net/1993/23775
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2013 Norah G. Verbout et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleImpact of Adiponectin Overexpression on Allergic Airways Responses in Mice
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
JA.2013.349520.xml
Size:
9.9 KB
Format:
Extensible Markup Language
Description:
Loading...
Thumbnail Image
Name:
JA.2013.349520.pdf
Size:
2.63 MB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.17 KB
Format:
Item-specific license agreed to upon submission
Description: