Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients

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dc.contributor.authorHuyen, V. T. T.
dc.contributor.authorPhan, D. V.
dc.contributor.authorThang, P.
dc.contributor.authorKy, P. T.
dc.contributor.authorHoa, N. K.
dc.contributor.authorOstenson, C. G.
dc.date.accessioned2015-05-14T16:17:52Z
dc.date.available2015-05-14T16:17:52Z
dc.date.issued2012-10-17
dc.date.updated2015-03-29T13:28:44Z
dc.description.abstractAims. To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients. Methods. After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks. Results. After 4-week SU treatment, fasting plasma glucose (FPG) and Hb decreased significantly (). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. Hb levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group (). Conclusion. GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.
dc.description.versionPeer Reviewed
dc.identifier.citationV. T. T. Huyen, D. V. Phan, P. Thang, P. T. Ky, N. K. Hoa, and C. G. Ostenson, “Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 452313, 7 pages, 2012. doi:10.1155/2012/452313
dc.identifier.urihttp://dx.doi.org/10.1155/2012/452313
dc.identifier.urihttp://hdl.handle.net/1993/30481
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2012 V. T. T. Huyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAntidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients
dc.typeJournal Article
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