Lipid interactions with the cardiac NaS+-HS+ exchanger
| dc.contributor.author | Goel, Danny Paul | en_US |
| dc.date.accessioned | 2007-07-12T19:42:44Z | |
| dc.date.available | 2007-07-12T19:42:44Z | |
| dc.date.issued | 2001-10-01T00:00:00Z | en_US |
| dc.degree.discipline | Physiology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Cardiac sarcolemmal Na+-H+ exchange is critical for the regulation of intracellular pH and its activity contributes to ischemia/reperfusion injury. It also plays an important role during ischemia/reperfusion injury in diabetics. The Na+-H + exchanger is altered during insulin-dependent diabetes mellitus, however, the mechanism for this inhibition has yet to be determined. Coincidentally, the cardiac sarcolemmal membrane phospholipids are also altered during insulin-dependent diabetes mellitus. It has been suggested that the membrane phospholipid environment does not modulate Na+-H+ exchange. The present study was carried out to determine the effects on Na+-H + exchange of modifying the endogenous membrane phospholipids through the addition of exogenous phospholipase AZ, phospholipase C, phospholipasase D, specific phospholipids and saturated and unsaturated fatty acids. The effects on Na+-H+ exchange of a direct addition of specific lipids to the sarcolemmal membrane was investigated. 22Na was utilized asa tracer to determine the amount of H +-dependent Na+ uptake. This study demonstrates that specific alterations in the cardiac sarcolemmal membrane phospholipids influence the activity of the Na+-H+ exchanger. (Abstract shortened by UMI.) | en_US |
| dc.format.extent | 7366273 bytes | |
| dc.format.extent | 184 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | text/plain | |
| dc.identifier.uri | http://hdl.handle.net/1993/2702 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.title | Lipid interactions with the cardiac NaS+-HS+ exchanger | en_US |
| dc.type | master thesis | en_US |