Browsing Rady Faculty of Health Sciences by Title
Now showing items 1013-1032 of 1640
-
National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research
(2021-03-19)Abstract Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of ... -
Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques
(PLOS, 2017-10-05)Cynomolgus macaques are an increasingly important nonhuman primate model for HIV vaccine research. SIV-free animals without pre-existing anti-SIV immune responses are generally needed to evaluate the effect of vaccine-induced ... -
Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
(2021-01-22)Abstract Background Hypertension is a major source of cardiovascular morbidity and mortality. Recent evidence from mouse models, genetic, and cross-sectional human studies ... -
Navigating uncharted territory: a qualitative study of the experience of transitioning to wheelchair use among older adults and their care providers
(2015-07-28)Abstract Background An increasing number of older adults are procuring a wheelchair for mobility; however, the corresponding impact on related injuries, caregiver burden, and ... -
Necrotizing Fasciitis Resulting from Human Bites: A Report of Two Cases of Disease Caused by Group A Streptococci
(2005-1-1)Necrotizing fasciitis is a serious and potentially life-threatening condition. Although bite wounds are common, they are not frequently reported as a cause of necrotizing fasciitis. In the present article, two cases of ... -
Necrotizing Lung Infection Caused by the Protozoan Balantidium coli
(2003-1-1)Balantidium coli, a ciliated protozoan, is well known to cause intestinal infection in humans. Extraintestinal spread to the peritoneal cavity and genitourinary tract has rarely been reported. There have also been a few ... -
Neonatal and Maternal Postpartum Bacteroides Bacteremia
(1999-1-1)OBJECTIVE: A unique case of Bacteroides fragilis bacteremia in a mother and her infant prompted a review of these infections in neonates and postpartum mothers during a five-year period at two institutions in Winnipeg, ... -
Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury
(2018-02-21)Abstract Background Spinal cord injury (SCI) triggers a robust neuroinflammatory response that governs secondary injury mechanisms with both degenerative and pro-regenerative ... -
Neurocognitive Changes in Student Athletes with and without a Concussion
(2017-08-04)Despite increased awareness in concussions, there is still minimal understanding of the physiological and psychological effects of concussion. To better understand concussion and the ensuing problems this injury can cause, ... -
Neurosurgical Outcomes in patients with Multiple Sclerosis related Trigeminal Neuralgia
(2016)Trigeminal neuralgia (TN) is a cranial nerve disorder that causes intense and debilitating unilateral facial pain. Medical therapy is usually initially effective to alleviate the pain, however, approximately 1/3 to 1/2 of ... -
New developments in transplant proteomics
(Wolters Kluwer Health, 2017-05)Purpose of review: Despite modern immunosuppression, renal allograft rejection remains a major contributor to graft loss. Novel biomarkers may help improve posttransplant outcomes through the early detection and treatment ... -
The Next Generation Cohort: Childhood Outcomes of Offspring of Parents with Early Onset Type 2 Diabetes
(2012-03-12)The Next Generation Birth Cohort has recruited 127 offspring of parents with youth-onset type 2 diabetes (T2DM)since 2003. Despite the high rate of awareness of the risks of obesity and T2DM in the offspring, 66% are ... -
NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus
(2012-05-03)AbstractBackgroundNuclear factor kappa B (NF-κB) is a transcription factor typically expressed with two specific subunits (p50, p65). Investigators have reported that NF-κB is activated during the induction of ... -
NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1
(2015-12-04)Abstract Background The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is required for pro-inflammatory effects of TNFα. Our previous studies demonstrated that PARP-1 ... -
Nimodipine therapy for juvenile ferrets with hydrocephalus
(2017-08-06)Hydrocephalus causes damage to periventricular white matter via compression, stretching, waste material accumulation, and ischemia. Nimodipine has been shown to provide benefits clinically in subarachnoid hemorrhage and ... -
Nimodipine treatment does not benefit juvenile ferrets with kaolin-induced hydrocephalus
(2018-05-03)Abstract Prior research on 3-week hydrocephalic rats showed that behavioral deficits and white matter damage could be reduced by treatment with Ca2+ channel blocker nimodipine. We hypothesized that treatment ... -
Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study
(2017-12-22)Abstract Background In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active ... -
Non invasive endothelial function testing and risk of adverse outcomes: systematic review literature search protocol
(2013-10-19)Includes terms list, databases and dates searched, literature search strategy (PubMed MEDLINE), benchmark papers list (by PMID). -
Non-IgE-mediated food hypersensitivity
(2018-09-12)Abstract Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly affect the gastrointestinal tract. This review will focus on the following more common ...