The treatment effects of dietary oils on diet-induced obesity, lipidemia, and insulin resistance in skeletal muscle tissue of obese prone rats

Thumbnail Image
Dunthorne, Karin
Journal Title
Journal ISSN
Volume Title
Reducing consumption of fat is recommended for obese individuals; however, altering dietary fat, without reducing total fat, may modify obesity-associated consequences. The effects of dietary fat composition on obesity and insulin resistance in diet-induced obese rats were investigated. Rats were fed a high-fat lard-based diet for 12 weeks and then were randomized into one of six high-fat treatment groups (oils used: high-oleic canola, conventional canola, high-oleic/conventional canola mix, conventional canola/flax mix, safflower, or soybean) or kept on the lard diet for 8 weeks. Diets had varying effects on lipidemia and glycemia; however, insulin tolerance tests, oral glucose tolerance tests, and the skeletal muscle response to insulin were not different among groups. Muscle phospholipids showed expected differences in fatty acid (FA) composition, but polyunsaturated/saturated FA ratios were not different among groups. Overall, a consistent response to high-fat diets was observed which may be attributed to the robustness of polyunsaturated/saturated FA ratios of muscle phospholipids.
Obesity, Metabolism, Nutrition, Diabetes, Canola, Oil