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    Indigestible cowpea proteins reduced plasma cholesterol after long-term oral administration to Sprague-Dawley rats

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    43014_2021_Article_61.pdf (1.112Mb)
    Date
    2021-06-16
    Author
    Alashi, Adeola M.
    Wu, Hongyi
    Aluko, Rotimi E.
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    Abstract
    Abstract Cowpea protein isolate (CPI) was subjected to various dry and wet heat pretreatments followed by sequential digestion with pepsin and pancreatin; the undigested residues were isolated as the indigestible cowpea proteins (ICPs). All the ICPs exhibited in vitro bile acid-binding capacity but ICP from the slow cooling-induced gelation had the highest yield (68%) and was used for rat feeding experiments to determine effect on plasma total cholesterol (TC). Groups consisting of 3 male and 3 female Sprague-Dawley rats each were fed hypercholesterolemic diets that contained casein only or casein that was partially substituted with ICP of CPI for 6 weeks. Results showed diet that contained 5% (w/w) ICP was more effective in preventing TC increase (1.8 mmol/L) when compared to increases of 9.34 and 4.15 mmol/L for CPI and casein only diets, respectively. Graphical abstract
    URI
    https://doi.org/10.1186/s43014-021-00061-1
    http://hdl.handle.net/1993/35732
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    • Faculty of Agricultural and Food Sciences Scholarly Works [97]
    • University of Manitoba Scholarship [1952]

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