New Biocide with Both N -Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activity
Considering the rise of antibiotic resistance, the development of new antibacterial agents with improved biocidal functions is urgently required. In this study, ionic 5,5-dimethylhydantoin (DMH) analogues containing either a quaternary ammonium moiety (2)–4) or a phosphonate functional group (5),–6), were designed and synthesized to investigate the possible enhancing effect of quaternary ammonium moieties on the antibacterial performance of N -chloramines. These ionic DMH analogues were converted to their N- chloramine counterparts either in free form or after being covalently immobilized on a polymer surface via the “click” chemistry method. In the subsequent antimicrobial assessment against multi-drug-resistant Escherichia coli (MDRE. coli ) and methicillin-resistant Staphylococcus aureus (MRSA), chlorinated 2 and 3, the cyclic N -chloramines with a structural cation, exhibited distinctly enhanced biocidal functions in solution and after immobilization on surfaces.
N-Chloramine, Quaternary Ammonium, biocides
Li, L.; Pu, T.; Zhanel, G.G.; Zhao, N.; Ens, W.; Liu, S.* New Biocide with Both N-Chloramine and Quaternary Ammonium Salt Moieties Exerts Enhanced Bactericidal Activity. Advanced Healthcare Materials, 2012; 1(5): 609-620.