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    Versatile surface biofunctionalization of poly(ethylene terephthalate) by interpenetrating polymerization of a butynyl monomer followed by “Click Chemistry”

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    Date
    2011-11-27
    Author
    Li, Lingdong
    Zhao, Nan
    Liu, Song
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    Abstract
    Biofunctionalization of poly(ethylene terephthalate) (PET) is crucial to its medical and biomedical applications such as surgical drapes, vascular grafts and ligament prostheses. To furnish PET with an alkynyl handle, N-(2-methylbut-3-yn-2-yl)acrylamide (MBAA) underwent photo-initiated copolymerization with N,N0-methylenebisacrylamide (MBA) in methanol-swollen PET surface to form a 3- dimensional interpenetrating network (IPN). The alkynyl handle terminated surface was denoted as PMBAA-PET. A region-selective modification could be achieved using an engraved mask during the photo-initiated copolymerization. Several functional azides including dansyl-azide 1, azido-5,5- dimethyl-hydantoin analog 2, per-azido-b-cyclodextrin (per-azido-b-CD) and azido-Bovine Serum Albumin (BSA-N3), were successfully bonded onto PMBAA-PET surface via Huisgen 1,3-dipolar cycloaddition. Kinetic study of the heterogeneous “click” reaction between PMBAA-PET and 1 was investigated using X-ray photoelectron spectroscopy (XPS) and elemental analysis. PMBAA-PET was rendered with effective biocidal activity against a healthcare-associated methicilin-resistant Staphylococcus aureus (HAMRSA) and a multi-drug-resistant Escherichia coli (MDR-E. coli) after 2 was conferred. Meanwhile, accessible CD cavity was determined and the amount of covalently immobilized BSA protein was also quantified after the respective “click” linkages of per-azido-b-CD and BSA-N3 on PMBAA-PET surface were established.
    URI
    http://hdl.handle.net/1993/33526
    DOI
    10.1016/j.polymer.2011.11.036
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    • Faculty of Agricultural and Food Sciences Scholarly Works [97]
    • University of Manitoba Scholarship [1978]

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