Finite element study of dominant stimulus in regulating femur bone remodeling

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Zhang, Yichen
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Based on the Wolff’s law, mechanical stimuli affect bone strength and therefore affect its bone mineral density (BMD) distribution. There are a number of mechanical stimuli, for example, von-Mises stress, tensile stress, compressive stress, and strain energy density (SED). It is not clear which is the dominant stimulus. The objective of this study was to determine the dominant stimulus that regulates femur BMD by iterative finite element simulations of Wolff’s law. Four finite element models of the same femur initially had the same uniform BMD and were affected by the same loading. In the iterative simulations, BMD in each model was ‘remodeled’ by one of the four stimuli. The results showed BMD distribution in the finite element model regulated by SED was closest to QCT measured BMD, followed by von-Mises stress, then tensile and compressive stress. It is thus concluded that SED was the dominant stimulus in regulating femur BMD.
Bone remodeling, Bone mineral density (BMD), Mechanical stimuli, Wolff’s law, Finite element simulation