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    Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population

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    Date
    2014-7-16
    Author
    Kong, Fei
    Pan, Yu
    Chi, Xiumei
    Wang, Xiaomei
    Chen, Linjiao
    Lv, Juan
    Sun, Haibo
    Wu, Ruihong
    Jin, Jinglan
    Yu, Ge
    Ma, Zhenhua
    Wang, Yang
    Huang, Xinxing
    Li, Hua
    Bai, Yang
    Jia, Jing
    Minuk, Gerald Y.
    Zhong, Jin
    Sun, Bing
    Jiang, Jing
    Niu, Junqi
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    Abstract
    Hepatitis C virus (HCV) infections spontaneously clear in approximately 15–45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.
    URI
    http://hdl.handle.net/1993/23749
    DOI
    10.1155/2014/527030
    Collections
    • Rady Faculty of Health Sciences Scholarly Works [1296]
    • University of Manitoba Scholarship [2009]

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