Innovative designs in tissue engineering: improvements on scaffold fabrication and bioreactor design

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dc.contributor.authorLi, Wen
dc.contributor.examiningcommitteeElmekkawy, Tarek (Mechanical and Manufacturing Engineering) Scanlon, Martin (Food Science)en_US
dc.contributor.supervisorXing, Malcolm (Mechanical and Manufacturing Engineering) Peng, Qingjin (Mechanical and Manufacturing Engineering)en_US
dc.date.accessioned2012-01-24T20:01:33Z
dc.date.available2012-01-24T20:01:33Z
dc.date.issued2012-01-24
dc.degree.disciplineMechanical and Manufacturing Engineeringen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThis study consists of two projects related to Tissue Engineering: Engineering biomimetic scaffolds for bone regeneration and ear reconstruction, and bioreactor design for ex-vivo bioengineered scaffold. The co-electrospinning method was used to produce composite membranes with different layers from gelatin and polycaprolactone (PCL) nanofibers, followed by paper-stacking cell seeded membranes to mimic the twisted plywood structure found in lobster cuticles. 3D laser scanner was used to capture the precise shape of a human ear model; and the negative molds were fabricated to compress scaffolds into the shape of human ear. Design for assembly (DFA) method was used to analyze and improve the design of the current bioreactor. A new design is proposed to ease operation, save time and increase the application efficiency. The proposed solution is evaluated in a virtual environment using 3D assembly modeling and simulation.en_US
dc.description.noteFebruary 2012en_US
dc.identifier.urihttp://hdl.handle.net/1993/5110
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectTissue Engineeringen_US
dc.subjectDesign for Assemblyen_US
dc.subjectScaffolden_US
dc.subjectVirtual Realityen_US
dc.titleInnovative designs in tissue engineering: improvements on scaffold fabrication and bioreactor designen_US
dc.typemaster thesisen_US
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