The natural history of youth onset type 2 diabetes mellitus
| dc.contributor.author | Dart, Allison | |
| dc.contributor.examiningcommittee | Brownell, Marni (Community Health Sciences) Sellers, Elizabeth (Pediatrics and Child Health) Rigatto, Claudio (Internal Medicine) | en |
| dc.contributor.supervisor | Martens, Patricia (Community Health Sciences) | en |
| dc.date.accessioned | 2010-04-13T11:58:58Z | |
| dc.date.available | 2010-04-13T11:58:58Z | |
| dc.date.issued | 2010-04-13T11:58:58Z | |
| dc.degree.discipline | Community Health Sciences | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Administrative data was anonymously linked to a clinical registry, to evaluate the validity of diabetes algorithms in youth. In addition, incident youth with T2DM (n=342) in Manitoba (1-18 years) from Jan.1986-2009 identified from the clinical registry were anonymously linked to healthcare records in order to evaluate complications, compared to youth with type 1 diabetes (T1DM) (n=1011) and non-diabetes (non-DM) controls (n=1710). The algorithm including 1 or more hospitalizations or two or more outpatient claims over two years was the most valid. Youth with T2DM had a 47% increased risk of any complication and a 2.29 fold increased risk of renal complication. Age at diagnosis, HgA1c and ace inhibitor/angiotensin receptor blocker use (ACE/ARB) were significant risk factors for any complication. Risk factors for renal complications included ACE/ARB use, albuminuria and diagnosis prior to 2000. Survival at 10 years was 91.4% (T2DM) vs. 99.5% (T1DM) vs. 100% (non-DM); p<0.0001. | en |
| dc.description.note | May 2010 | en |
| dc.format.extent | 2249545 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1993/3978 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | youth | en |
| dc.subject | diabetes | en |
| dc.subject | validation | en |
| dc.subject | renal | en |
| dc.subject | complication | en |
| dc.title | The natural history of youth onset type 2 diabetes mellitus | en |
| dc.type | master thesis | en_US |