The effect of α-solanine on acetylcholinesterase activity in vivo, an examination of undocumented beliefs
| dc.contributor.author | Walker, Airdrie M. | en_US |
| dc.date.accessioned | 2007-05-15T15:18:13Z | |
| dc.date.available | 2007-05-15T15:18:13Z | |
| dc.date.issued | 1997-05-01T00:00:00Z | en_US |
| dc.degree.discipline | Botany | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | The present study examined the effect of $\alpha$-solanine in vivo under controlled experimental conditions. The study examined the effect of $\alpha$-solanine on cholinesterase enzyme activity at two levels of dietary protein. The study showed that intraperitoneal $\alpha$-solanine at 1 mg/Kg B.W. inhibited the cholinesterase activity in the liver but only at 12 hours post-injection in the animals fed the standard protein diet. The study examined the relationship between dietary factors and the anti-cholinesterase effect which has not been studied previously. The effect of low dietary protein was evident in all tissues but was only significantly different in the liver. In the liver, a significant difference in enzyme activity was observed in both the low and standard protein groups at all three time points. In other tissues there was a reduction in activity due to the low protein diet but it was not statistically significant. This study suggests that the anti-cholinesterase effect of $\alpha$-solanine is afactor in the toxicity of animals resulting from the ingestion of potato glyoalkaloids and toxicity may be greater in animals with inadequate nutritional status. (Abstract shortened by UMI.) | en_US |
| dc.format.extent | 6718982 bytes | |
| dc.format.extent | 184 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | text/plain | |
| dc.identifier.uri | http://hdl.handle.net/1993/823 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.title | The effect of α-solanine on acetylcholinesterase activity in vivo, an examination of undocumented beliefs | en_US |
| dc.type | master thesis | en_US |