Extracellular S100A4 induces human thyroid cancer cell migration

Simple item page
dc.contributor.authorMedapati, Manoj Reddy
dc.contributor.examiningcommitteeKlonisch, Thomas (Human Anatomy & Cell Science) Keijzer, Richard (Surgery)en_US
dc.contributor.supervisorHombach-Klonisch, Sabine (Human Anatomy & Cell Science)en_US
dc.date.accessioned2013-08-28T15:01:52Z
dc.date.available2013-08-28T15:01:52Z
dc.date.issued2013-08-28
dc.degree.disciplineHuman Anatomy and Cell Scienceen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractHuman thyroid cancer is the most commonly occurring cancer of the endocrine gland having good survival rate, but some patients show recurrence with an invasive phenotype and treatment failures. The mechanisms behind this invasive phenotype are not well understood in TC. Previously our group has identified a pro-migratory role of relaxin-like peptides in thyroid cancer that is mediated by S100A4. We have observed in human TC cells that extracellular S100A4 induces migration and activates ERK1/2, JNK/SAPK and NFkB signaling pathways. Employing immunohistochemistry and immunofluorescence we have identified the expression of RAGE in human TC primary cells, cell lines, and in tumor tissues but not in normal thyroid tissues. We showed that S100A4 binds to RAGE in TC cells and that RAGE and its cytoplasmic partner Dia-1 mediate the S100A4-induced migration of TC cells. This study identified a crucial role of RAGE in TC cell migration induced by S100A4.en_US
dc.description.noteOctober 2013en_US
dc.identifier.urihttp://hdl.handle.net/1993/22120
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectTCen_US
dc.subjectThyroid Canceren_US
dc.subjectRAGEen_US
dc.subjectReceptor for Advanced Glycation End Productsen_US
dc.subjectDMen_US
dc.subjectDistant Metastasisen_US
dc.subjectDia-1en_US
dc.subjectDiaphanous-1en_US
dc.titleExtracellular S100A4 induces human thyroid cancer cell migrationen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Medapati_Manoj Reddy.pdf
Size:
2.06 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica