Negative pressure pulmonary edema, a clinical review and study of its pathophysiology
| dc.contributor.author | Tauriainen, M. Peter | en_US |
| dc.date.accessioned | 2007-05-15T15:21:27Z | |
| dc.date.available | 2007-05-15T15:21:27Z | |
| dc.date.issued | 1997-07-01T00:00:00Z | en_US |
| dc.degree.discipline | Surgery | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | This experiment studied the pathophysiology of negative pressure pulmonary edema. Laser colorimetry, weight transients, hematocrit and plasma protein changes were used to determine fluid and protein flux in 3 groups of isolated blood-perfused left lower canine lung lobes. Each group (n = 12) was subjected to an initial 50 minute control period with a capillary pressure $\rm(P\sb{c})$ of 15 cm H$\sb2$O and pleural pressure $\rm(P\sb{pl})$ of $-$5 cm H$\sb2$O. Group 1 was subjected to a further 50 minutes of perfusion with the same conditions. Transpulmonary pressure was increased in the other two groups from 20 to 30 cm H$\sb2$O for 50 minutes by decreasing P$\rm\sb{pl}$ in group 2 (preferentially affecting extra-alveolar vessels) and by increasing P$\rm\sb{c}$ in group 3 (affecting alveolar and extra-alveolar vessels). There were no differences in fluid flux between initial and final filtration periods in Group 1 by laser colorimetry (0.333 vs. 0.431 ml/gm dry weight/hour). Group 2 had a significant increase in filtration during the final filtration period. Group 3 filtration also increased. Weight transients overestimated edema compared to hematocrit and laser colorimetry derived values. Filtrate to plasma protein concentrations (CF/CP) decreased in Groups 2 and 3 but did not change significantly in Group 1. No differences in CF/CP could be detected based on plasma protein concentrations. Negative pleural pressures significantly increased pulmonary fluid filtration with the majority of the increase taking place in the extra-alveolar vessels. Filtrate protein concentration changes suggest that the increased filtration appears due to increased surface area and/or increased hydrostatic forces, not from a permeability change. (Abstract shortened by UMI.) | en_US |
| dc.format.extent | 3747558 bytes | |
| dc.format.extent | 184 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | text/plain | |
| dc.identifier.uri | http://hdl.handle.net/1993/923 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.title | Negative pressure pulmonary edema, a clinical review and study of its pathophysiology | en_US |
| dc.type | master thesis | en_US |