Association of killer immunoglobulin-like receptor (KIR) genes with tuberculosis disease in two Canadian cohorts

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dc.contributor.authorBraun, Kali
dc.contributor.examiningcommitteeBall, T. Blake (Medical Microbiology) Larcombe, Linda (Medical Microbiology) Brassinga, Ann Karen (Microbiology)en_US
dc.contributor.supervisorSharma, Meenu (Medical Microbiology)en_US
dc.date.accessioned2013-08-19T21:02:35Z
dc.date.available2013-08-19T21:02:35Z
dc.date.issued2013-07en_US
dc.degree.disciplineMedical Microbiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractIn Canada, and more specifically in Canadian-born Aboriginals and foreign born populations, high incidence of tuberculosis (TB) causes significant morbidity and mortality. The presence or absence of specific killer immunoglobulin-like receptor (KIR) genes, individually or in conjunction, may be associated with tuberculosis (active, latent, or uninfected disease status) as well as ethnicity of an individual. It is hypothesized that the differences in KIR profiles, gene frequencies, and/or haplotypes in Canadian-born Aboriginal, Canadian-born non-Aboriginal, and foreign born individuals elicits a differential activation or inhibition profile, resulting in differential cytokine expression and eventually contributes to the outcome of TB infection. In this study we examined the enrichment or depletion of KIR genes in different ethnic populations in Manitoba with special focus on active, latent, and uninfected TB status. In addition, we sought to explore the statistical correlation between TB status and inhibitory/stimulatory KIR haplotypes.en_US
dc.description.noteOctober 2013en_US
dc.identifier.citation8(7):e67842en_US
dc.identifier.urihttp://hdl.handle.net/1993/22042
dc.language.isoengen_US
dc.publisherPLoS ONEen_US
dc.rightsopen accessen_US
dc.subjecttuberculosisen_US
dc.subjectKIRen_US
dc.subjectkiller immunoglobulin-like receptoren_US
dc.subjectAboriginalen_US
dc.titleAssociation of killer immunoglobulin-like receptor (KIR) genes with tuberculosis disease in two Canadian cohortsen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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