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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/6206

Title: Role of caveolin-1 in airway hyper-responsiveness and inflammation in response to house dust mite challenge
Authors: Hynes, Tyler
Supervisor: Halayko, Andrew (Physiology)
Examining Committee: Bshouty, Zoheir (Physiology) Kroeger, Ed (Physiology) Peng, Zhikang (Immunology)
Graduation Date: October 2012
Keywords: caveolin-1
asthma
hyperresponsiveness
airway
inflammation
physiology
Issue Date: 15-May-2012
Abstract: Allergic asthma is a syndrome characterized by respiratory distress in response to environmental triggers. This atypical response to an allergen is an over reaction of the immune system causing an influx of inflammatory cells into the airway and concomitant airway smooth muscle constriction. Firstly, we demonstrate using whole house dust mite (HDM) extract as a sensitizing allergen produces an equivalent or more robust hyperresponsive and inflammatory reaction than can be achieved with the widely used ovalbumin (OVA) sensitization / challenge protocol. Secondly, we investigated the role of caveolin-1 in the pathophysiology of allergic asthma . Our data suggest an important role for cav-1 in down regulating allergic airway inflammation, leading to reduced airways hyperresponsiveness and mucus overproduction.
URI: http://hdl.handle.net/1993/6206
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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