MSpace - DSpace at UofM >
Faculty of Graduate Studies (Electronic Theses and Dissertations) >
FGS - Electronic Theses & Dissertations (Public) >

Please use this identifier to cite or link to this item:

Title: Role of caveolin-1 in airway hyper-responsiveness and inflammation in response to house dust mite challenge
Authors: Hynes, Tyler
Supervisor: Halayko, Andrew (Physiology)
Examining Committee: Bshouty, Zoheir (Physiology) Kroeger, Ed (Physiology) Peng, Zhikang (Immunology)
Graduation Date: October 2012
Keywords: caveolin-1
Issue Date: 15-May-2012
Abstract: Allergic asthma is a syndrome characterized by respiratory distress in response to environmental triggers. This atypical response to an allergen is an over reaction of the immune system causing an influx of inflammatory cells into the airway and concomitant airway smooth muscle constriction. Firstly, we demonstrate using whole house dust mite (HDM) extract as a sensitizing allergen produces an equivalent or more robust hyperresponsive and inflammatory reaction than can be achieved with the widely used ovalbumin (OVA) sensitization / challenge protocol. Secondly, we investigated the role of caveolin-1 in the pathophysiology of allergic asthma . Our data suggest an important role for cav-1 in down regulating allergic airway inflammation, leading to reduced airways hyperresponsiveness and mucus overproduction.
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

Files in This Item:

File Description SizeFormat
Hynes_Tyler.pdf3.3 MBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback