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dc.contributor.supervisor Liu, Song (Textile Sciences) en_US
dc.contributor.author Kulkarni, Abhilash
dc.date.accessioned 2012-10-29T18:57:25Z
dc.date.available 2012-10-29T18:57:25Z
dc.date.issued 2012-10-29
dc.identifier.uri http://hdl.handle.net/1993/9816
dc.description.abstract The problems and high medical costs associated with chronic wounds necessitate an economical bioactive wound dressing. A new strategy was investigated to inhibit MMP-9 proteases and to release epidermal growth factor (EGF) to enhance healing. Doxycycline (DOX) and EGF were encapsulated on polyacrylic acid modified polyurethane film (PAA-PU) using Layer-by-Layer (LbL) assembly. The number of bilayers tuned the concentration of DOX and EGF released over time with over 94% bioactivity of EGF retained over 4 days. A simple wound model in which MMP-9 proteases were added to cell culture containing fibroblast cells demonstrated that DOX inhibited the proteases providing a protective environment for the released EGF to stimulate cell migration and proliferation at a faster healing rate. In the presence of DOX, only small amounts of the highly bioactive EGF are sufficient to close the wound. Results show that this is new and promising bioactive dressing for effective wound management. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Chronic wounds en_US
dc.subject Layer-by-Layer assembly en_US
dc.subject Epidermal growth factor en_US
dc.subject Doxycycline en_US
dc.title Effective delivery of doxycycline and epidermal growth factor for expedited healing of chronic wounds. en_US
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Textile Sciences en_US
dc.contributor.examiningcommittee Diehl-Jones, William (Biological Sciences) Horne, Lena (Textile Sciences) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2013 en_US


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