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dc.contributor.author Ash, Cecil Samuel en_US
dc.date.accessioned 2007-05-15T15:20:41Z
dc.date.available 2007-05-15T15:20:41Z
dc.date.issued 1997-05-01T00:00:00Z en_US
dc.identifier.uri http://hdl.handle.net/1993/899
dc.description.abstract Objective. To examine (1) the predictability of the orthopantomogram (OPG) in detecting mandibular bone invasion by oral squamous cell carcinoma (SCC), and (2) the independent effect of mandibular bone invasion on disease-free survival. Study design. A population based retrospective review of 107 patients with biopsy proven SCC of the floor of mouth, lower alveolus, and retromolar tr gone, who required mandibular resection as part of their treatment was undertaken. Each patient received an OPG which was compared with the histologic findings of bone invasion. Results. The OPG identified 62% of patients with bone invasion by oral SCC. The OPG's lack of sensitivity (positivity in disease) however, allows for a relatively high incidence of false negative interpretations. With the multivariate model, two variables, advanced clinical stage disease and deep bone invasion were found to be of prognostic relevance. Clinical stage of disease was determined to be a confounding variable of deep bone invasion, and after controlling for the effect of advanced clinical stage disease on disease-free survival, the independent effect of deep bone invasion failed to achieve statistical significance (p = 0.0845). Conclusion. The OPG is a useful initial assessment of mandibular bone invasion by oral SCC, however, it lacks the sensitivity to detect the early stages of bone invasion. In this study, mandibular bone invasion was not shown to be prognostically significant for disease-free survival. Therefore, further investigations are unnecessary to determine if focal invasion of the mandible is present. It is more important to achieve with a marginal or segmental mandibular resection a clear resection margin. (Abstract shortened by UMI.) en_US
dc.format.extent 4710631 bytes
dc.format.extent 184 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language en en_US
dc.language.iso en_US
dc.title Mandibular invasion in oral squamous cell carcinoma en_US
dc.degree.discipline Surgery en_US
dc.degree.level Master of Science (M.Sc.) en_US


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