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dc.contributor.supervisor Suh, Miyoung (Human Nutritional Sciences) en_US
dc.contributor.author McClinton, Kathleen
dc.date.accessioned 2012-09-14T21:49:05Z
dc.date.available 2012-09-14T21:49:05Z
dc.date.issued 2012-09-14
dc.identifier.uri http://hdl.handle.net/1993/8862
dc.description.abstract While carotenoids are essential for visual function, their potential role in diabetic retinopathy is not known. By providing carrot powder, this study examined carotenoid metabolism and visual function in Type 1 diabetes. Wistar rats (n=30) were assigned to diet either with or without carrot enrichment (15%, w/w) for 12 weeks. Type 1 diabetes was induced with streptozotocin at 3 weeks. Retinal function and anatomical integrity were assessed along with retinoid and carotenoid levels in the serum, liver, and retina. Loss of ERG oscillatory potentials, with normal histology indicated early stage retinopathy. Healthy animals fed carrot diet showed highest b-wave amplitudes; reflecting higher phototransduction. Diabetic animals fed carrot diet had the lowest b-wave amplitudes, reduced retinoids liver reserves, and highest α- and β-carotene, suggesting disturbance of conversion during diabetes. Consequently carrot powder at concentrations used by this study cannot be recommended for diabetic retinopathy. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject type 1 diabetes en_US
dc.subject carotenoids en_US
dc.subject retinoids en_US
dc.subject retinopathy en_US
dc.subject nutrition en_US
dc.subject UPLC en_US
dc.title The effects of carrot carotenoids on diabetic retinopathy in Type 1 diabetes mellitus en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Human Nutritional Sciences en_US
dc.contributor.examiningcommittee Aliani, Michel (Human Nutritional Sciences) Sauve, Yves (Ophthalmology, University of Alberta) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2012 en_US


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